| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-18721550-091 18721550091 |
| Email: |
yangdong@pharma.com |
| Products Intro: |
Product Name:RO6889678
CAS:1578153-27-1
Purity:>95% Package:5 mg|10 mg| Remarks:MC017748
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| | RO6889678 Basic information |
| Product Name: | RO6889678 | | Synonyms: | RO6889678;3-Morpholinecarboxylic acid, 4-[[(6R)-6-(2-chloro-4-fluorophenyl)-3,6-dihydro-5-(methoxycarbonyl)-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (3S)-;inhibit,Hepatitis B virus,coregulated protein,UDP-glucuronosyltransferase,HB capsid formation,ADME,CYP3A4,RO-6889678,RO6889678,hepatocytes,CYPs,Cytochrome P450,UGT1A3,oxidation,RO 6889678,HBV,UGT1A1,Inhibitor,glucuronidation | | CAS: | 1578153-27-1 | | MF: | C21H20ClFN4O5S | | MW: | 494.92 | | EINECS: | | | Product Categories: | | | Mol File: | 1578153-27-1.mol |  |
| | RO6889678 Chemical Properties |
| | RO6889678 Usage And Synthesis |
| Description | RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. | | in vitro | RO6889678 is a highly potent inhibitor of HBV capsid formation, with attributes that are favorable for targeting the liver while maintaining moderate peripheral exposure._x000D_
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Reference: J Pharmacol Exp Ther. 2018 May;365(2):237-248. https://pubmed.ncbi.nlm.nih.gov/29453199/ | | target | RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. |
| | RO6889678 Preparation Products And Raw materials |
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