| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:NCT-505
CAS:2231079-74-4
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:NCT-505;inhibit,Aldehyde Dehydrogenase (ALDH),NCT-505,Inhibitor,NCT505,NCT 505
CAS:2231079-74-4
Purity:98% Package:1 mg;10 mg;100 mg;25 mg;5 mg;50 mg
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| | NCT-505 Basic information |
| Product Name: | NCT-505 | | Synonyms: | NCT-505 free base;4-Piperidinecarbonitrile, 1-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]-4-phenyl-;1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile;inhibit,Aldehyde Dehydrogenase (ALDH),NCT-505,Inhibitor,NCT505,NCT 505 | | CAS: | 2231079-74-4 | | MF: | C27H28FN5O3S | | MW: | 521.61 | | EINECS: | | | Product Categories: | | | Mol File: | 2231079-74-4.mol |  |
| | NCT-505 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | NCT-505 Usage And Synthesis |
| Description | NCT-505 is an Orally Bioavailable aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitor with Potent Cellular Activity (IC50 = 7 nM). NCT-505 demonstrated target engagement in a cellular thermal shift assay (CETSA), inhibited the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiated the cytotoxicity of paclitaxel in SKOV-3-TR, a paclitaxel resistant ovarian cancer cell line. NCT-505 also exhibit high specificity over other ALDH isozymes and unrelated dehydrogenases. |
| | NCT-505 Preparation Products And Raw materials |
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