| Company Name: |
Adamas Reagent, Ltd.
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| Tel: |
400-6009262 16621234537 |
| Email: |
chenyj@titansci.com |
| Products Intro: |
Product Name:N-(4-(Aminomethyl)-2,6-Dimethylphenyl)-5-(2,5-Dichlorophenyl)Furan-2-Carboxamide
CAS:1314212-39-9
Purity:98% Package:100mg;250mg;1g
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:CYM50358
CAS:1314212-39-9
Purity:>=98% Package:500Mg;1g;5g;25g;100g;500g;1kg;5kg
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| | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Basic information |
| Product Name: | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) | | Synonyms: | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358);CYM50358;CYM50358 >=98% (HPLC);N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide;CYM50358,LPL Receptor,Lysophospholipid Receptor,CYM-50358,Inhibitor,CYM 50358,inhibit,S1PR4;2-Furancarboxamide, N-[4-(aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)- | | CAS: | 1314212-39-9 | | MF: | C20H18Cl2N2O2 | | MW: | 389.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1314212-39-9.mol |  |
| | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Chemical Properties |
| Boiling point | 463.5±45.0 °C(Predicted) | | density | 1.329±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (321.11 mM; Need ultrasonic) | | form | Solid | | pka | 12.40±0.70(Predicted) | | color | Off-white to yellow |
| | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Usage And Synthesis |
| Biological Activity | CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2].
CYM50358 shows less potent inhibition of S1PR1 (IC50=6.4 μM)[1].CYM50358 (10 μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phosphorylation of HSP27[2]. | | References | [1]. Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. [2]. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100. |
| | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) Preparation Products And Raw materials |
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