7,8-二氢-D-新蝶呤
| 中文名称 | 7,8-二氢-D-新蝶呤 |
|---|---|
| 中文同义词 | 7,8-二氢-D-新蝶呤;化合物 7,8-DIHYDRONEOPTERIN |
| 英文名称 | 7,8-DIHYDRONEOPTERIN |
| 英文同义词 | 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;Dihydroneopterin;NEOPTERIN, 7,8-DIHYDRO-D;7,8-DIHYDRO-D-NEOPTERIN;7,8-DIHYDRONEOPTERIN;4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]- |
| CAS号 | 1218-98-0 |
| 分子式 | C9H13N5O4 |
| 分子量 | 255.23 |
| EINECS号 | |
| 相关类别 | 生物活性小分子;Heterocycles, Nucleotides, Bases & Related Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 1218-98-0.mol |
| 结构式 |  |
7,8-二氢-D-新蝶呤 性质
| 熔点 | >167°C (dec.) |
|---|---|
| 沸点 | 614.6±65.0 °C(Predicted) |
| 密度 | 2.03±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于酸性水溶液（少许）、DMSO（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.88±0.20(Predicted) |
| 颜色 | 淡黄色低 |
| BRN | 1133875 |
7,8-Dihydroneopterin 是一种炎症标记，通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。
Apoptosis; iNOS
7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .
Cell Viability Assay
| Cell Line: | Astrocytic cell line U373MG |
| Concentration: | 0.1, 0.5, 1, 2.5, 5 mM |
| Incubation Time: | 2 days and 5 days |
| Result: |
After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-136341 | 7,8-二氢-D-新蝶呤 7,8-Dihydroneopterin | 1 mg | 600元 | |
| 2024/11/08 | HY-136341 | 7,8-二氢-D-新蝶呤 7,8-Dihydroneopterin | 1218-98-0 | 5mg | 1500元 |