UK-157147
| 中文名称 | UK-157147 |
|---|---|
| 中文同义词 | 化合物 T19597 |
| 英文名称 | UK-157147 |
| 英文同义词 | UK-157147;3(2H)-Pyridazinone, 6-[[(3S,4R)-3,4-dihydro-3-hydroxy-6-[(3-hydroxyphenyl)sulfonyl]-2,2,3-trimethyl-2H-1-benzopyran-4-yl]oxy]-2-methyl- |
| CAS号 | 162704-20-3 |
| 分子式 | C23H24N2O7S |
| 分子量 | 472.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 162704-20-3.mol |
| 结构式 |  |
UK-157147 性质
| 熔点 | 138-165 °C |
|---|---|
| 沸点 | 659.2±65.0 °C(Predicted) |
| 密度 | 1.40±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.51±0.10(Predicted) |
UK-157147 是一种 UDP-葡萄糖醛酸转移酶 (UGT1A1) 的底物，Km 值为 105 μM。
Km: 105 μM (UGT1A1)
Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) are used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The para phenol UK-157147 (UK-157,147) is found to be a substrate for UGT1A1 with a K m value of 105 μM.