BAY 1316957)

BAY 1316957) Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BAY-1316957
CAS:1613264-40-6
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:BAY 1316957)
CAS:1613264-40-6
Purity:98%+ HPLC Package:100MG,500MG,1G,5G,10G 50MG
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:BAY-1316957
CAS:1613264-40-6
Package:100mg;1280USD|50mg;789USD
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:BAY-1316957
CAS:1613264-40-6
Purity:98% Package:$150.9/5mg;$250.9/10mg;$550.9/25mg;$950.9/50mg;$1550.9/100mg;Bulk package Remarks:98%
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:BAY 1316957
CAS:1613264-40-6
Purity:98% Package:2mg;5mg;25mg

BAY 1316957) manufacturers

  • BAY-1316957
  • BAY-1316957 pictures
  • $1280.00 / 100mg
  • 2024-10-24
  • CAS:1613264-40-6
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
BAY 1316957) Basic information
Product Name:BAY 1316957)
Synonyms:BAY 1316957);BAY-1316957 (BAY1316957;1H-Benzimidazole-5-carboxylic acid, 2-(9-ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-methyl-
CAS:1613264-40-6
MF:C27H27N3O3
MW:441.52
EINECS:
Product Categories:
Mol File:1613264-40-6.mol
BAY 1316957) Structure
BAY 1316957) Chemical Properties
Boiling point 646.3±65.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (226.49 mM; Need ultrasonic)
form Solid
pka2.10±0.30(Predicted)
color White to off-white
Safety Information
MSDS Information
BAY 1316957) Usage And Synthesis
Biological ActivityBAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R. BAY-1316957 has excellent drug metabolism and pharmacokinetics properties, and can be used for endometriosis research[1]. BAY-1316957 (Compound 32) shows high solubility and permeability using the Caco-2 cellular assay[1]. BAY-1316957 (Compound 32; 0.2-5 mg/kg; oral administration; once) treatment significantly reduces mechanical allodynia in dmPGE2 pain model[1].The pharmacokinetic parameters of BAY-1316957 (Compound 32) shows a low clearance, long half-life, and high bioavailability (F%=90%) in Wistar rats. Investigation of the metabolic pathways of BAY-1316957 (Compound 32) in human, rat, mouse, dog, and monkey hepatocytes revealed that the formation of the acyl glucuronide was also the common and predominant route of biotransformation, mainly catalyzed by UGT1A1 and to a lesser extent by UGT1A3[1].
References[1]. B?urle S, et al. Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis. J Med Chem. 2019 Mar 14;62(5):2541-2563.
BAY 1316957) Preparation Products And Raw materials
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