CHMFL-PI3KD-317
| 中文名称 | CHMFL-PI3KD-317 |
|---|---|
| 中文同义词 | 化合物 T10804;化合物CHMFL-PI3KD-317 |
| 英文名称 | CHMFL-PI3KD-317 |
| 英文同义词 | CHMFL-PI3KD-317;CHMFL-PI-3KD-317,CHMFLPI3KD317,CHMFL PI3KD 317;Butanamide, 2-amino-N-[5-[6-chloro-5-[[(3-methylphenyl)sulfonyl]amino]-3-pyridinyl]-4-methyl-2-thiazolyl]-3-methyl-, (2S)- |
| CAS号 | 2244992-76-3 |
| 分子式 | C21H24ClN5O3S2 |
| 分子量 | 494.03 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2244992-76-3.mol |
| 结构式 |  |
CHMFL-PI3KD-317 性质
| 密度 | 1.406±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 6.25±0.50(Predicted) |
|
PI3Kδ 6 nM (IC 50 ) |
PI3Kα 62.6 nM (IC 50 ) |
PI3Kβ 284 nM (IC 50 ) |
PI3Kγ 202.7 nM (IC 50 ) |
PIK3C2B 882.3 nM (IC 50 ) |
Vps34 1801.7 nM (IC 50 ) |
PI4KIIIA 574.1 nM (IC 50 ) |
PI4KIIIB 300.2 nM (IC 50 ) |
CHMFL-PI3KD-317 has antiproliferative effects, with GI 50 s of 3.5 ± 0.8, 4.0 ± 0.9, 4.8 ± 0.2, 3.3 ± 0.2, 3.0 ± 0.4 μM against PF382, NALM-6, MV4-11, MOLM-14 and MOLM-13 cells, respectively.
CHMFL-PI3KD-317 (Compound 15i; 25, 50 and 100 mg/kg/day, p.o., for 14 days) inhibits the growth of the MOLM14 tumor in mice.
CHMFL-PI3KD-317 shows favorable oral bioavailability and acceptable half-life (T
1/2
= 3.28 h) in Sprague-Dawley rats.
| Animal Model: | Female nu/nu mice bearing MOLM-14 tumor xenografts |
| Dosage: | 25, 50 and 100 mg/kg/day |
| Administration: | P.O. for 14 days |
| Result: | Inhibited the growth of the MOLM14 tumor without mortality or obvious weight loss in mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-112608 | CHMFL-PI3KD-317 | 1 mg | 1360元 | |
| 2024/04/30 | HY-112608 | CHMFL-PI3KD-317 CHMFL-PI3KD-317 | 2244992-76-3 | 5 mg | 3400元 |