IDH1 INHIBITOR 1
中文名称 | IDH1 INHIBITOR 1 |
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中文同义词 | 化合物 T11613 |
英文名称 | IDH1 Inhibitor 1 |
英文同义词 | 2-Oxazolidinone, 4-(fluoromethyl)-3-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]-1H-imidazol-4-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)-;IDH1 Inhibitor 1;IDH-1 Inhibitor 1,IDH1 Inhibitor 1 |
CAS号 | 2234285-81-3 |
分子式 | C20H18F4N6O2 |
分子量 | 450.39 |
EINECS号 | |
相关类别 | |
Mol文件 | 2234285-81-3.mol |
结构式 |
IDH1 INHIBITOR 1 性质
储存条件 | 4°C, away from moisture and light |
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形态 | 固体 |
颜色 | 白色至米白色 |
IC50: 0.021 μM (IDH1 R132H ), 0.045 μM (IDH1 R132C ), and 2.52 μM (IDH1 WT )
IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1 R132H/+ with an IC 50 of 0.039 μM.
IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1 R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-112601 | IDH1 Inhibitor 1 | 1 mg | 3120元 | |
2024/08/19 | HY-112601 | IDH1 INHIBITOR 1 IDH1 Inhibitor 1 | 2234285-81-3 | 5 mg | 7800元 |