| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PH11
CAS:1627843-95-1
Purity:详情请点击官网 Package:1 mg
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| Product Name: | PH11 | | Synonyms: | PH11;Benzoic acid, 2-[[4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a]-1,3,5-triazin-2-yl]amino]-, methyl ester | | CAS: | 1627843-95-1 | | MF: | C22H22N6O5 | | MW: | 450.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1627843-95-1.mol |  |
| density | 1.37±0.1 g/cm3(Predicted) | | pka | 5.26±0.30(Predicted) |
| Description | PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies. |
| | PH11 Preparation Products And Raw materials |
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