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| | CHLORMETHIAZOLE HYDROCHLORIDE Basic information |
| Product Name: | CHLORMETHIAZOLE HYDROCHLORIDE | | Synonyms: | 4-methyl-5-(β-chloroethyl)thiazole hydrochloride;Somnevrin hydrochloride;4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride;CloMethiazole Hydrochloride;Clomethiazole hydrochloride salt;Chlormethiazole Hydrochloride >;Inhibitor,Clomethiazole,Chlormethiazole hydrochloride,Chlormethiazole,inhibit;CHLORMETHIAZOLE HYDROCHLORIDE | | CAS: | 6001-74-7 | | MF: | C6H9Cl2NS | | MW: | 198.11336 | | EINECS: | | | Product Categories: | Heterocycles | | Mol File: | 6001-74-7.mol |  |
| | CHLORMETHIAZOLE HYDROCHLORIDE Chemical Properties |
| Melting point | 130℃ | | storage temp. | Desiccate at RT | | solubility | H2O: >10 mg/mL, soluble | | form | crystalline | | color | off-white | | Merck | 14,2384 | | Stability: | Hygroscopic |
| | CHLORMETHIAZOLE HYDROCHLORIDE Usage And Synthesis |
| Uses | Chlormethiazole Hydrochloride was used in the study of effect of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. | | Biochem/physiol Actions | Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug. | | Drug interactions | Potentially hazardous interactions with other drugs
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by
ritonavir.
Cimetidine: inhibits metabolism of clomethiazole. | | Metabolism | Clomethiazole is extensively metabolised, probably by
first-pass metabolism in the liver with only small amounts
appearing unchanged in the urine. The rate of elimination
is decreased by about 30% in liver cirrhosis. |
| | CHLORMETHIAZOLE HYDROCHLORIDE Preparation Products And Raw materials |
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