| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:Tat-NR2B9c TFA
CAS:1834571-04-8
Purity:98 Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement. Remarks:100mg
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| | Tat-NR2B9c TFA Basic information |
| | Tat-NR2B9c TFA Chemical Properties |
| storage temp. | Store at -20°C | | Water Solubility | Water : ≥ 50 mg/mL (18.99 mM) |
| | Tat-NR2B9c TFA Usage And Synthesis |
| Description | Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].
EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]p38[2] | | References | [1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15.
[2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009. |
| | Tat-NR2B9c TFA Preparation Products And Raw materials |
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