| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:SRS16-86
CAS:1793052-96-6
Purity:>98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:2g
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:SRS16-86
CAS:1793052-96-6
Purity:98% HPLC LCMS Package:100MG;1G
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:SRS16-86
CAS:1793052-96-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
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| | SRS16-86 Basic information |
| Product Name: | SRS16-86 | | Synonyms: | SRS16-86;Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester;(Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate;IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86 | | CAS: | 1793052-96-6 | | MF: | C26H32N4O2 | | MW: | 432.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1793052-96-6.mol |  |
| | SRS16-86 Chemical Properties |
| Boiling point | 614.9±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | pka | 5.58±0.20(Predicted) | | color | Yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| | SRS16-86 Usage And Synthesis |
| Description | SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2 | | Definition | ChEBI: SRS16-86 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM. It has a role as a ferroptosis inhibitor. It is a tert-butyl ester, a member of adamantanes, a member of pyrimidines, a substituted aniline, a secondary amino compound and an imine. | | References | Linkermann et al. (2014), Synchronized renal tubular cell death involves ferroptosis; Proc. Natl. Acad. Sci. USA. 111 16841
Zhang et al. (2019), Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury; Brain Res. 1706 48 |
| | SRS16-86 Preparation Products And Raw materials |
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