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4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

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4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:B022
CAS:1202764-53-1
Purity:98.00% Package:10 mg；100 mg；200 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:B022
CAS:1202764-53-1
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:B022
CAS:1202764-53-1
Purity:99% Package:$205.9/5mg;$350.9/10mg;$1250.9/50mg;$2200.9/100mg;Bulk package Remarks:99%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Products Intro: Product Name:B022
CAS:1202764-53-1
Purity:98% Package:1g;10g;100g
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Products Intro: Product Name:B022
CAS:1202764-53-1
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Basic information
Product Name:4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol
Synonyms:4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol;B022;2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-;B022,B-022
CAS:1202764-53-1
MF:C19H16ClN5OS
MW:397.88
EINECS:
Product Categories:
Mol File:1202764-53-1.mol
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Structure
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Chemical Properties
Boiling point 644.4±65.0 °C(Predicted)
density 1.53±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (628.33 mM)
form Solid
pka10.71±0.29(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Usage And Synthesis
Biological ActivityB022 is a potent and selective NF-κB-inducible kinase (NIK) inhibitor with Ki of 4.2 nM. B022 protects the liver from inflammation, oxidative stress and damage caused by toxins.
in vitro

B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner.
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

Western Blot Analysis

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Suppressed NIK-induced p52 formation in a dose-dependent manner. td>

RT-PCR

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
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in vivo

B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses. < /p>

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Animal Model: STOP-NIK male mice (8 weeks) infected with Ad-cre
Dosage: 30 mg/kg
Administration: Intravenous injection; twice a day; for 10 days
Result: Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.
target

Ki: 4.2 nM (NF-κB-inducing kinase (NIK))

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Preparation Products And Raw materials
Tag:4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol(1202764-53-1) Related Product Information