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BOC Sciences
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Product Name:SKF 83959 hydrobromide
CAS:67287-95-0
Purity:≥98% by HPLC Remarks:SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki = 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors, respectively), exhibiting anti-Parkinsonian effects and anta
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:SKF 83959 (hydrobromide)
CAS:67287-95-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | SKF 83959 Basic information |
| Product Name: | SKF 83959 | | Synonyms: | SKF 83959;N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide;SKF-83959 HBr | | CAS: | 67287-95-0 | | MF: | C18Cl1H20N1O2 | | MW: | 398.72 | | EINECS: | | | Product Categories: | | | Mol File: | 67287-95-0.mol |  |
| | SKF 83959 Chemical Properties |
| Melting point | 263-265 °C | | storage temp. | Store at RT | | solubility | DMSO: 26 mg/mL, soluble | | form | solid | | color | white |
| | SKF 83959 Usage And Synthesis |
| Description | SKF 83959 is a partial agonist at the dopamine D1-like receptors (Kis = 1.18 and 7.56 nM, respectively, for D1 and D5) that is selective over the D2-like receptors (Kis = 920 and 399 nM, respectively, for D2 and D3). It is protective against oxidative stress in retinal ganglion cells after hydrogen peroxide-induced injury in vitro. In a rat methylazoxymethanol acetate (MAM) model of schizophrenia, it had positive effects on hippocampal function, determined using electrophysiology, but impaired spatial learning. SKF 83959 can also act as an allosteric modulator of the sigma-1 (σ1) receptor by enhancing the binding to and delaying the dissociation of the selective σ1-receptor agonist pentazocine. | | Uses | SKF 83959 is a D1-like partial agonist. | | Definition | ChEBI: A hydrobromide salt prepared from N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM
or rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine. | | Hazard | A poison. | | storage | Store at RT |
| | SKF 83959 Preparation Products And Raw materials |
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