| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:T-448
CAS:1597426-53-3
Purity:98% HPLC Package:100mg，250mg，1g
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| | T-448 Chemical Properties |
| storage temp. | Store at -20°C, stored under nitrogen | | solubility | DMSO : 16.67 mg/mL (43.13 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | T-448 Usage And Synthesis |
| Biological Activity | T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].
T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction[1].
T-448 has minimal impact on the LSD1-GFI1B complex and a superior hematological safety profile in mice via the generation of a compact formyl-FAD adduct. T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction[1].T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg[1]. | | References | [1]. Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22. |
| | T-448 Preparation Products And Raw materials |
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