| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:C 021 dihydrochloride
CAS:1784252-84-1
Purity:99% Package:1G;10G;100G Remarks:C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
CAS:1784252-84-1
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| | C-021 dihydrochloride Basic information |
| Product Name: | C-021 dihydrochloride | | Synonyms: | Inhibitor,C 021 dihydrochloride,CCL22,CCR4,C021,C021 dihydrochloride,CCR,C 021,CC chemokine receptor,inhibit,C-021,GTPγS,chemotaxis;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride | | CAS: | 1784252-84-1 | | MF: | C27H42ClN5O2 | | MW: | 504.12 | | EINECS: | | | Product Categories: | | | Mol File: | 1784252-84-1.mol |  |
| | C-021 dihydrochloride Chemical Properties |
| solubility | DMSO: 25 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | C-021 dihydrochloride Usage And Synthesis |
| Description | Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4.1 It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day.2 It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin when administered intrathecally at doses ranging from 10 to 30 μg/animal.3 | | storage | Desiccate at RT | | References | 1. Yokoyama, K., Ishikawa, N., Igarashi, S., et al. Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines Bioorg. Med. Chem. 16(14),7021-7032(2008).
2. McMillin, M., Frampton, G., Thompson, M., et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline J. Neuroinflammation 11,121(2014).
3. Bogacka, J., Ciapa?a, K., Pawlik, K., et al. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia - Evidence from a mouse model of diabetic neuropathy Neuroscience 441,77-92(2020). |
| | C-021 dihydrochloride Preparation Products And Raw materials |
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