PDEδ-IN-99
| 中文名称 | PDEδ-IN-99 |
|---|---|
| 中文同义词 | K-RAS-PDEΔ-IN-1;N-(4-氟苯乙基)-4-(4-甲基-7-氧代-2-(对甲苯基)-2H-吡唑并[3,4-D]哒嗪-6(7H)-基)丁酰胺;化合物K-RAS-PDEΔ-IN-1 |
| 英文名称 | PDEδ-IN-99 |
| 英文同义词 | PDEδ-IN-99;N-(4-fluorophenethyl)-4-(4-methyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide;K-Ras-PDEδ-IN-1;6H-Pyrazolo[3,4-d]pyridazine-6-butanamide, N-[2-(4-fluorophenyl)ethyl]-2,7-dihydro-4-methyl-2-(4-methylphenyl)-7-oxo-;N-(4-Fluorophenethyl)-4-(4-methyl-7-oxo-2-(p-tolyl)-2H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)butanamide;KRasPDEδIN1,PDEδ,cancer,pyrazolopyridazinone-based,inhibit,K Ras PDEδ IN 1,Inhibitor,Phosphodiesterase (PDE);PDEδ-IN-99 |
| CAS号 | 1841464-21-8 |
| 分子式 | C25H26FN5O2 |
| 分子量 | 447.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1841464-21-8.mol |
| 结构式 |  |
PDEδ-IN-99 性质
| 密度 | 1.27±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,Room Temperature |
| 形态 | 固体 |
| 酸度系数(pKa) | 15.85±0.46(Predicted) |
| 颜色 | 白色至米白色 |
|
PDE4 8.3 nM (Kd) |
K-Ras-PDEδ-IN-1 exhibits an IC 50 value of 12.3 μM in PaTu8902/Panc1 CTG assay.
K-Ras-PDEδ-IN-1 (oral or intraperitoneal injection; 10 mg/kg; single dose) is in different vehicles (A=5% Tween-80, 50% NaCl, 45% H2O; B=20% DMSO, 80% PEG200; C=15% DMSO, 9.5% Cremophor EL/EtOH (1:1), 75.5 % H2O) for oral and intraperitoneal (IP) administration.whereas only very low compound levels are found in plasma after oral dosage, but significantly higher plasma concentrations are found after IP administration in vehicle A, B or C at 10 mg kg.K-Ras-PDEδ-IN-1 (intravenous injection; 3 mg kg; single dose; 24 hours) shows a significant increase of the plasma exposure as well as the terminal half-life (t 1/2 =0.4 hours)when compares to compound 93,exhibits a t 1/2 , CO, AUC 0-tz , AUC 0.inf-obs , Cl obs , and Vss 0-inf-obs values of 4.1 hours, 2790.9 ng/ml, 1646.4 h.ng/ml, 1662.5 h.ng/ml, 1.8 L/h/kg, 5.9 l/kg.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-115555 | K-Ras-PDEδ-IN-1 | 1 mg | 1090元 | |
| 2024/04/30 | HY-115555 | PDEδ-IN-99 K-Ras-PDEδ-IN-1 | 1841464-21-8 | 5mg | 2400元 |