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Focus Biomolecules
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Product Name:Compound 115-7c
CAS:908074-72-6
Purity:98% by TLCNMR (Conforms) Package:$90.00/5mg;$360.00/25mg;
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| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050 |
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| Products Intro: |
Product Name:HSP70 modulator 115-7c
CAS:908074-72-6
Purity:98% Package:10mg 100mg
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| | HSP70 modulator 115-7c Basic information |
| Product Name: | HSP70 modulator 115-7c | | Synonyms: | HSP70 modulator 115-7c;1(2H)-Pyrimidinebutanoic acid, 4-(2,4-dichlorophenyl)-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-;Compound 115-7c | | CAS: | 908074-72-6 | | MF: | C23H22Cl2N2O5 | | MW: | 477.34 | | EINECS: | | | Product Categories: | | | Mol File: | 908074-72-6.mol |  |
| | HSP70 modulator 115-7c Chemical Properties |
| Boiling point | 688.6±55.0 °C(Predicted) | | density | 1.360±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 20 mg/ml). | | pka | 4.73±0.10(Predicted) | | form | solid | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| | HSP70 modulator 115-7c Usage And Synthesis |
| Description | Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1?The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.2?Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.3,4?Compound 115-7c is an important probe for understanding HSP70 functions.4 | | Definition | ChEBI: 4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid is a carboxylic ester. It is functionally related to a benzyl alcohol. | | References | 1) Wisen?et al. (2010),?Binding of a small molecule at the protein-protein interface regulates the chaperone activity of hsp70-hsp40;? ACS Chem. Biol.,?5?611
2) Jinwal?et al. (2010),?Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;? Mol. Cell Pharmacol.,?2?43
3) Chafekar?et al. (2012),?Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;? ACS Chem. Biol.,?7?1556
4) Walter?et al. (2011),?Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;? J. Biol. Chem.,?286?40486 |
| | HSP70 modulator 115-7c Preparation Products And Raw materials |
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