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| [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Basic information |
Product Name: | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- | Synonyms: | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-;SU0268;SU-0268 (SU0268);MCF-7,Inhibitor,cGAS,OGG1,SU0268,A549,SU 0268,STING,IRF3,inhibit,HeLa,glycosylase,antibacterial,SU-0268;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide | CAS: | 2210228-45-6 | MF: | C26H25N3O4S | MW: | 475.56 | EINECS: | | Product Categories: | | Mol File: | 2210228-45-6.mol | |
| [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Chemical Properties |
storage temp. | -20°C | solubility | Soluble in DMSO (10 mg/ml) | form | solid | color | Off-white | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Usage And Synthesis |
Description | SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3 | References | Tahara et al. (2018), Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase; J. Am. Chem. Soc., 140 2105
Kant et al. (2021), Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products if Oxidatively induced DNA Base Lesions; ACS Chem. Biol., 16 45
Qin et al. (2020), Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection; J. Immunol., 205 2231 |
| [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Preparation Products And Raw materials |
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