| Company Name: |
Block Chemical Technology (Shanghai) Co., Ltd.
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| Tel: |
021-20432219 13918097649 |
| Email: |
li_jinfei@acblock-lab.com |
| Products Intro: |
Product Name:Roflupram >=98% (HPLC)
CAS:1093412-18-0
Purity:98% Package:1g Remarks:instock Binx2
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Roflupram >=98% (HPLC)
CAS:1093412-18-0
Purity:NULL Package:1ea;25mg;5mg Remarks:NULL
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:FFPM
CAS:1093412-18-0
Package:2mg/RMB 720;5mg/RMB 1230;25mg/RMB 5380
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| | 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Basic information |
| | 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (318.15 mM; Need ultrasonic) | | form | Liquid | | color | Colorless to light yellow |
| | 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Usage And Synthesis |
| Biological Activity | Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2]. | | References | [1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176.
[2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392. |
| | 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Preparation Products And Raw materials |
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