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Tauro-α-muricholic acid sodium salt

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Products Intro: Product Name:Tauro-α-muricholic acid sodium salt
CAS:2260905-08-4
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CAS:2260905-08-4
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CAS:2260905-08-4
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Products Intro: Product Name:Tauro-α-muricholic acid sodium salt
CAS:2260905-08-4
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Products Intro: Product Name:Tauro-α-muricholic acid sodium salt
CAS:2260905-08-4
Purity:98% Package:5g；10g；20g；100g；100kg
Tauro-α-muricholic acid sodium salt Basic information
Product Name:Tauro-α-muricholic acid sodium salt
Synonyms:2-[[(3α,5β,6β,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt
CAS:2260905-08-4
MF:C26H46NNaO7S
MW:539.7
EINECS:
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Mol File:2260905-08-4.mol
Tauro-α-muricholic acid sodium salt Structure
Tauro-α-muricholic acid sodium salt Chemical Properties
storage temp. Store at -20°C
solubility DMF: 10 mg/mL; DMSO: 10 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 1 mg/mL
form A crystalline solid
color White to off-white
Safety Information
MSDS Information
Tauro-α-muricholic acid sodium salt Usage And Synthesis
DescriptionTauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.2
References1. Sayin, S.I., Wahlstr?m, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012).
Tauro-α-muricholic acid sodium salt Preparation Products And Raw materials
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