H3B-120
中文名称 | H3B-120 |
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中文同义词 | N1-苄基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺;化合物H3B-120 |
英文名称 | H3B-120 |
英文同义词 | H3B-120;N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide;H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120;1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)- |
CAS号 | 2194903-42-7 |
分子式 | C19H24N4O2S |
分子量 | 372.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 2194903-42-7.mol |
结构式 |
H3B-120 性质
密度 | 1.280±0.06 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:62.5 mg/mL(167.79 mM) |
酸度系数(pKa) | 8.28±0.70(Predicted) |
形态 | 固体 |
颜色 | 米白色至黄色 |
Target | Value |
CPS1
(Cell-free assay) | 1.4 μM(Ki) |
CPS1
(Cell-free assay) | 1.5 μM |
H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-136128 | H3B-120 | 1 mg | 500元 | |
2024/08/19 | HY-136128 | N1-苄基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺 H3B-120 | 2194903-42-7 | 5mg | 980元 |