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LQZ-7I

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LQZ-7I Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:LQZ-7I
CAS:195822-23-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:LQZ-7I
CAS:195822-23-2
Purity:99.9% Package:5mg;47USD|10mg;80USD|25mg;163USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:LQZ 7I
CAS:195822-23-2
Purity:98% Package:5mg Remarks:V2178
Company Name: Nanjing Doge Biomedical Technology Co., Ltd
Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Products Intro: Product Name:LQZ-7I
CAS:195822-23-2
Package:5g;100g;1KG;25KG
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:LQZ-7I
CAS:195822-23-2
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

LQZ-7I manufacturers

  • LQZ-7I
  • LQZ-7I pictures
  • $47.00 / 5mg
  • 2024-11-19
  • CAS:195822-23-2
  • Min. Order:
  • Purity: 99.9%
  • Supply Ability: 10g
LQZ-7I Basic information
Product Name:LQZ-7I
Synonyms:LQZ-7I;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
CAS:195822-23-2
MF:C20H14F2N4
MW:348.35
EINECS:
Product Categories:
Mol File:195822-23-2.mol
LQZ-7I Structure
LQZ-7I Chemical Properties
Melting point 203 °C(Solv: ethanol (64-17-5))
Boiling point 470.3±45.0 °C(Predicted)
density 1.390±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO: 125 mg/mL (358.83 mM)
form A solid
pka2.56±0.59(Predicted)
color Light yellow to green yellow
Safety Information
MSDS Information
LQZ-7I Usage And Synthesis
Biological ActivityLQZ-7I is an inhibitor targeting survivin. It can inhibits survivin dimerization and xenograft tumor growth and induces loss of survivin in the tumor.
in vitro

LQZ-7I has improved cytotoxicity with IC 50 s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin .

Western Blot Analysis

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Cell Line: PC- 3 or C4-2 cells
Concentration: 10 μM
Incubation Time: 0-6 hours
Result: Reduced the expression of survivin.
in vivo

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.

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Animal Model: 6-week old male NSG mice
Dosage: 100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO)
Administration: Oral gavage every other day for a total of ten treatments
Result: Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.
target

Survivin

LQZ-7I Preparation Products And Raw materials
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