N-Acetyl lysyltyrosylcysteine amide 是一种有效的,可逆的,特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤,并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成,蛋白质硝化和 LDL 氧化。
N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.
Animal Model:
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8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
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Dosage:
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10 mg/kg
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Administration:
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I.p.; daily for 3-7 days
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Result:
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Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
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