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Nanjing Shizhou Biology Technology Co.,Ltd
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Product Name:DODECA-2(E)-DIENOIC ACID ISOBUTYLAMIDE
CAS:24738-51-0
Purity:98% Package:5mg 10mg
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| Company Name: |
Focus Biomolecules
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855-362-8721 |
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sales@focusbiomolecules.com |
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Product Name:Dienamide A2
CAS:24738-51-0
Purity:98% by TLCNMR (Conforms) Package:$60.00/5mg;$240.00/25mg;
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| Company Name: |
BBT INC
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022-58613671 58613672 |
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tiyfkj@hotmail.com |
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| | DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Basic information |
| | DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | LogP | 4.962 (est) |
| | DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Usage And Synthesis |
| Description | Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1?Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive? but not in CB2-negative cells and this effect was blocked by SR144528.2??It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2 | | Uses | Kalecide is a natural pesticide of Echinacea angustifolia, Echinacea atrorubens and Piper sarmentosum. | | Definition | ChEBI: (2E,4E)-N-isobutyl-2,4-dodecadienamide is a fatty amide. It has a role as a metabolite. | | References | 1) Gertsch?et al. (2004), Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways; FEBS Lett., 577?563
2) Raduner?et al. (2006), Alkylamides from Echinacea are a new class of cannabinomimetics.? Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects; J. Biol. Chem., 281?14192 |
| | DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Preparation Products And Raw materials |
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