| Company Name: |
Neobioscience Co., Ltd.
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| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:Anti-CCDC88A
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| | ANTI-HAP1 Basic information |
| Product Name: | ANTI-HAP1 | | Synonyms: | MONOCLONAL ANTI-AP ENDONUCLEASE;ANTI-REF-1;ANTI-APEN;ANTI-AP L;ANTI-APE;ANTI-APE1;ANTI-APE/REF-1;ANTI-APEX | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HAP1 Structure]() |
| | ANTI-HAP1 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| | ANTI-HAP1 Usage And Synthesis |
| Biological Activity | The gene HAP1 (huntingtin-associated protein 1) is a bifunctional enzyme th at functions as a DNA repair enzyme as well as in redox activation of transcription factors. It binds to the Huntingtonμs disease (HD) protein huntingtin in a polyglutamine length-dependent manner. It associates with huntingtin via the cytoskeletal proteins dynactin and pericentriolar autoantigen protein 1 forming coiled-coils. It plays a role in vesicle trafficking by facilitating interactions among cytoskeletal, vesicular and motor proteins. It is an apurinic/apyrimidinic (AP) site-specific DNA repair endonuclease th at removes the AP sites produced naturally or by cytotoxic drugs and radiation. It also has RNAse H activity and controls the redox state of certain proto-oncogene products, such as the transcription factor c-Jun. The HAP1 protein is a candidate for pathology associated with HD. |
| | ANTI-HAP1 Preparation Products And Raw materials |
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