| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:whole antiserum, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
VWR International
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| Tel: |
800 932 5000 |
| Email: |
solutions@vwr.com |
| Products Intro: |
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| Company Name: |
Nacalai Tesque, Inc.
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| Tel: |
81 75 251 1723 |
| Email: |
info-tech@nacalai.co.jp |
| Products Intro: |
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| | ANTI-GI ALPHA-3 (GIALPHA3) Basic information |
| | ANTI-GI ALPHA-3 (GIALPHA3) Chemical Properties |
| storage temp. | -20°C | | form | aqueous glycerol solution |
| | ANTI-GI ALPHA-3 (GIALPHA3) Usage And Synthesis |
| Uses | Anti-Gα i3 antibody produced in rabbit is suitable for immunoprecipitation at a working antibody amount of 4μL using solubilized mouse brain membrane lysates and immunoblotting at a working dilution of 1:2000 using solubilized mouse and rat brain membrane lysates, and mouse 3T3 cell lysates. | | General Description | G-proteins are membrane associated heterotrimeric proteins that are comprised of α-, β-, and λ-subunits. These proteins play a key role in signal transduction pathways that regulate cell′s response to several hormones, neuromodulators and ligands. | | Biochem/physiol Actions | Gi α 3 is a G-protein subunit that is involved in many signal transduction pathways including the mediation of EGF-induced PLC-γ activation and Ca+2 mobilization in hepatocytes. The α-subunit contains a guanine-binding domain that is in its inactive state when it is occupied by GDP. Upon activation, GDP is replaced with GTP, causing the dissociation of the α-subunit from the βλ-subunit complex. This enables the Gα-GTP complex to bind to and regulate specific signaling pathways. GTP is then hydrolyzed, allowing for re-association of the α-subunit with the βλ-subunit complex. |
| | ANTI-GI ALPHA-3 (GIALPHA3) Preparation Products And Raw materials |
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