| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:AR453588
CAS:1065609-00-8
Purity:95% Package:2mg;5mg;25mg
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| Company Name: |
RD International Technology Co., Limited
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| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:AR453588
CAS:1065609-00-8
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| | AR453588 Basic information |
| Product Name: | AR453588 | | Synonyms: | AR453588;AR-453588,AR453588;Ethanone, 1-[4-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-(2-pyridinylthio)-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]-1-piperidinyl]- | | CAS: | 1065609-00-8 | | MF: | C25H25N7O2S2 | | MW: | 519.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1065609-00-8.mol |  |
| | AR453588 Chemical Properties |
| Boiling point | 737.3±70.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (192.44 mM; Need ultrasonic) | | pka | 5.15±0.10(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | AR453588 Usage And Synthesis |
| Biological Activity | AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity[1].
AR453588 (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice[1].AR453588 (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14 day ob/ob mouse[1].AR453588 (10 mg/kg; p.o.) treatment shows that the Tmax, AUCinf, Vss, Cmax and F are 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively[1].AR453588 (1 mg/kg; i.v.) treatment shows that the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively[1]. | | References | [1]. Hinklin RJ, et al. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem. 2020 Jan 1;28(1):115232. |
| | AR453588 Preparation Products And Raw materials |
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