| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:c-Kit-IN-2
CAS:2121515-37-3
Purity:0 Package:1mg
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| | c-Kit-IN-2 Basic information |
| Product Name: | c-Kit-IN-2 | | Synonyms: | c-Kit-IN-2;c Kit IN 2,cKitIN2;Urea, N-(5-ethyl-3-isoxazolyl)-N'-[4-[2-[[6-(4-ethyl-1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolyl]phenyl]- | | CAS: | 2121515-37-3 | | MF: | C25H29N9O2S | | MW: | 519.62 | | EINECS: | | | Product Categories: | | | Mol File: | 2121515-37-3.mol |  |
| | c-Kit-IN-2 Chemical Properties |
| density | 1.367±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12.62±0.70(Predicted) |
| | c-Kit-IN-2 Usage And Synthesis |
| Description | c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
IC50: 82 nM (c-KIT)[1] | | References | [1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957. |
| | c-Kit-IN-2 Preparation Products And Raw materials |
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