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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Suppliers list
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Products Intro: Product Name:SCR130；1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-
CAS:2377858-38-1
Package:10 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:SCR130
CAS:2377858-38-1
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Products Intro: Product Name:SCR130
CAS:2377858-38-1
Purity:98% Package:$68.9/5mg;$88.9/10mg;$206.9/25mg;$315.9/50mg;$568.9/100mg;$1279.9/250mg;Bulk pac Remarks:98%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
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Products Intro: Product Name:SCR130
CAS:2377858-38-1
Purity:98% Package:1g;10g;100g
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Products Intro: Product Name:SCR130
CAS:2377858-38-1
Purity:98% Package:5mg Remarks:S23391
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Basic information
Product Name:1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-
Synonyms:1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-;SCR130;DNA/RNA Synthesis,NHEJ,Inhibitor,SCR130,Apoptosis,Ligase-IV,DNA,anticancer,p-p53,SCR 130,cytotoxicity,inhibit,SCR-130;2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4,5]dec-1-ene-6,10-dione;SCR130, 10 mM in DMSO
CAS:2377858-38-1
MF:C19H13Cl2N3O2S
MW:418.3
EINECS:
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Mol File:2377858-38-1.mol
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Structure
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Chemical Properties
density 1.57±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka7.30±0.60(Predicted)
form Solid
color Light yellow to brown
Safety Information
MSDS Information
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Usage And Synthesis
UsesSCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor. SCR130 inhibits the end-joining of DNA in a Ligase IV-dependent manner. SCR130 is specific to Ligase IV, and shows minimal or no effect on Ligase III and Ligase I mediated joining. SCR130 induces cell apoptosis and has anticancer activity[1].
References[1] Ujjayinee Ray, et al. Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics. Mol Carcinog. 2020 Jun;59(6):618-628. DOI:10.1002/mc.23186
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Preparation Products And Raw materials
Tag:1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-(2377858-38-1) Related Product Information
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