| Company Name: |
Leancare Ltd.
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| Tel: |
+33 962096793 |
| Email: |
enquiry@leancare.co.uk |
| Products Intro: |
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| | niceritrol Basic information |
| Product Name: | niceritrol | | Synonyms: | niceritrol | | CAS: | | | MF: | C29H24N4O8 | | MW: | 0 | | EINECS: | 227-519-7 | | Product Categories: | | | Mol File: | Mol File | ![niceritrol Structure]() |
| | niceritrol Chemical Properties |
| | niceritrol Usage And Synthesis |
| Originator | Cardiolipol,Gremy-Longuet,France,1972 | | Manufacturing Process | 160 grams of nicotinic acid chloride is charged into and made to react with 35
grams of pentaerythritol dissolved in 600 grams of dried, stabilized chloroform
and 100 grams of carefully dried pyridine. Pyridine hydrochloride, pyridine and
the excess of nicotinic acid chloride are removed through repeated extraction
with water at a pH of approximately 3. Pentaerythritol nicotinate remains in
the chloroform phase and is extracted by forming the hydrochloric acid salt of
the ester using 1,000 ml of aqueous HCl at a pH of 1. The strongly acid
extract is thereafter extracted several times with toluene. The acid extract is
allowed to stand at room temperature for several hours in the presence of
active carbon and the substance known as Versenate, i.e., the disodium salt of
ethylene diamine tetraacetic acid; it is then filtered and pentaerythritol
nicotinate is precipitated as a white, amorphous substance using 25% w/v
aqueous ammonia, while stirring. Recrystallization of the product from ethyl
alcohol gives flaky crystals, according to British Patent 1,022,880. | | Therapeutic Function | Antihyperlipidemic |
| | niceritrol Preparation Products And Raw materials |
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