| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:N-Eicosanoyl serotonin
Purity:98% by TLCNMR (Conforms) Package:$50.00/10mg;$180.00/50mg;
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| | N-Eicosanoyl Serotonin Basic information |
| | N-Eicosanoyl Serotonin Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming) | | form | solid | | color | Beige | | Stability: | Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | N-Eicosanoyl Serotonin Usage And Synthesis |
| Description | N-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. ?It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3 | | Uses | N-Eicosanoyl Serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease | | References | 1) Yan?et al.?(2018),?Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB; Proc. Natl. Acad. Sci. USA,?115?E12053
2) Asam?et al. (2017),?Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid; PLoS One,?12?e0189413
3) Basurto-Islas?et al.?(2014),?Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease; Neurobiol. Aging,?35?2701 |
| | N-Eicosanoyl Serotonin Preparation Products And Raw materials |
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