| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:TP0586532
CAS:2427584-96-9
Purity:98% HPLC LCMS Package:100MG;1G
|
| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:TP0586532
CAS:2427584-96-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:TP0586532
CAS:2427584-96-9
Purity:98% HPLC Package:100mg，250mg，1g
|
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| | TP0586532 Basic information |
| Product Name: | TP0586532 | | Synonyms: | TP0586532;3-Azabicyclo[3.1.0]hexane-3-butanoic acid, 6-[2-[4-[3-[[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]methyl]-5-isoxazolyl]phenyl]ethynyl]-, (1α,5α,6-exo,6α)- | | CAS: | 2427584-96-9 | | MF: | C26H28N4O4 | | MW: | 460.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2427584-96-9.mol |  |
| | TP0586532 Chemical Properties |
| Boiling point | 712.1±60.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (108.57 mM; Need ultrasonic) | | form | Solid | | pka | 4.44±0.10(Predicted) | | color | White to off-white |
| | TP0586532 Usage And Synthesis |
| Biological Activity | TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].
TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1]. | | References | [1]. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964. |
| | TP0586532 Preparation Products And Raw materials |
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