| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
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| Tel: |
18149758185 18149758185 |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:Mesdopetam L-tartrate salt
CAS:2562346-14-7
Purity:98% Package:100g/;10g/;1g/ Remarks:1g
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:Mesdopetam hemitartrate
CAS:2562346-14-7
Purity:98% HPLC Package:100mg，250mg，1g
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Mesdopetam L-tartrate salt manufacturers
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| | Mesdopetam L-tartrate salt Basic information |
| Product Name: | Mesdopetam L-tartrate salt | | Synonyms: | Mesdopetam L-tartrate salt;3-?dihydroxybutanedioat?e (2:1);IRL790 hemitartrate;Mesdopetam hemitartrate;N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-;1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1);Dopamine Receptor,properties,neurotransmission,inhibit,stabilizing,disease,psychomotor,Mesdopetam hemitartrate,Inhibitor,Parkinson;Mesdopetam · 1/2 L-tartrate salt | | CAS: | 2562346-14-7 | | MF: | C16H24FNO9S | | MW: | 425.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2562346-14-7.mol |  |
| | Mesdopetam L-tartrate salt Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 20.83 mg/mL (29.72 mM; ultrasonic and warming and heat to 60°C) | | form | Solid | | color | White to off-white |
| | Mesdopetam L-tartrate salt Usage And Synthesis |
| Biological Activity | Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease[1][2].
Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].Mesdopetam (10 mg/kg; intraperitoneally; fourteen-week-old male C57BL/J mice) hemitartrate promotes a sedative effect similar to haloperidol with significantly reduced total distance traveled and reduced average speed[2]. | | References | [1]. Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020;374(1):113-125.
[2]. Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133. |
| | Mesdopetam L-tartrate salt Preparation Products And Raw materials |
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