| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:CU-CPD107
CAS:2573912-32-8
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CU-CPD107
CAS:2573912-32-8
Purity:98.86% Package:50 mg；10 mg；5 mg；100 mg；1 mg；；
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| | 1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Basic information |
| | 1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Chemical Properties |
| Boiling point | 513.0±50.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 80 mg/mL (199.87 mM);Ethanol: 80 mg/mL (199.87 mM) | | pka | 14.60±0.29(Predicted) | | Water Solubility | Water: Insoluble |
| | 1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Usage And Synthesis |
| Biological Activity | CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1] | | References | [1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351. |
| | 1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Preparation Products And Raw materials |
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