| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:AZ2;AZ-2
CAS:2231760-33-9
Purity:98% Package:100 mg;25 mg;50 mg
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:AZ2
CAS:2231760-33-9
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
|
| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:AZ2
CAS:2231760-33-9
Purity:>=99% Package:5mg;50mg;10mM*1mLinDMSO;10mg;25mg;500mg;100mg;200mg
|
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| | Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Basic information |
| | Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Chemical Properties |
| density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (135.33 mM; Need ultrasonic) | | pka | 9.49±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Usage And Synthesis |
| Biological Activity | AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 can be used for the research of inflammatory and immune diseases[1].
AZ2 (0.1~100 nM; 1 hour; SKOV-3 cells) excellent selectivity for PI3Kγ is further confirmed with a constitutively activated PI3K/Akt pathway[1]. | | References | [1]. Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15(4):348-357. |
| | Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Preparation Products And Raw materials |
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