| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
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Product Name:(-)-Bicuculline Methiodide;[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-diMethyl-1,3-dioxolo[4,5-g]isoquinoliniuMiodide
CAS:40709-69-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:1(S),9(R)-()-Bicuculline methiodide
CAS:40709-69-1
Purity:>= 95.0 % HPCE Package:10mg, 50mg, 250mg Remarks:14343
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:(-)-Bicuculline methiodide
CAS:40709-69-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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(-)-Bicucullinemethiodide manufacturers
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| | (-)-Bicucullinemethiodide Basic information |
| Product Name: | (-)-Bicucullinemethiodide | | Synonyms: | [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-;1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;(-)-Bicuculline methiodide;(-)-Bicuculline methiodide
DISCONTINUED. offer B382505;( ) Bicuculline methiodide,()Bicuculline methiodide;(5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide | | CAS: | 40709-69-1 | | MF: | C21H20INO6 | | MW: | 0 | | EINECS: | | | Product Categories: | GABA/Glycine receptor | | Mol File: | 40709-69-1.mol |  |
| | (-)-Bicucullinemethiodide Chemical Properties |
| RTECS | JI4904100 | | storage temp. | Store at RT | | solubility | H2O: soluble10mg/mL, almost clear, greenish-yellow | | form | Pale yellow solid. | | color | Yellow | | optical activity | [α]/D -117±7°, c = 1 in chloroform | | BRN | 5419649 |
| WGK Germany | 3 | | HazardClass | 6.1 |
| | (-)-Bicucullinemethiodide Usage And Synthesis |
| Uses | 1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs). | | General Description | Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP). | | Biological Activity | Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels. | | Biochem/physiol Actions | (-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor. | | storage | Room temperature |
| | (-)-Bicucullinemethiodide Preparation Products And Raw materials |
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