| Company Name: |
Shochem(Shanghai)Co.,Ltd
|
| Tel: |
+86-021-51783479 +86-13816874662 |
| Email: |
info@shochem.com |
| Products Intro: |
Product Name:113-O12B
CAS:2803699-72-9
Purity:98% Package:1g;10g
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:113-O12B
CAS:2803699-72-9
Purity:98% HPLC Package:100mg，250mg，1g
|
| Company Name: |
Shanghai Easy CDMO Co.,Ltd
|
| Tel: |
021-61734564 |
| Email: |
August@easycdmo.com |
| Products Intro: |
Product Name:INDEX NAME NOT YET ASSIGNED
CAS:2803699-72-9
Purity:98% Package:5g；10g；20g；100g；100kg
|
| Company Name: |
Shochem (Shanghai) Co.,Ltd
|
| Tel: |
13611745246 13816874662 |
| Email: |
sales@shochem.com |
| Products Intro: |
Product Name:113-O12B
CAS:2803699-72-9
Purity:98% Package:1g;10g;100g
|
|
| | INDEX NAME NOT YET ASSIGNED Basic information |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 1025.1±65.0 °C(Predicted) | | density | 1.095±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Ethanol: 10 mg/ml | | pka | 7.73±0.50(Predicted) |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Biological Activity | 113-O12B is a disulfide bond-containing ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model. | | References | 1.Chen, J., Ye, Z., Huang, C., et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell responseProc. Natl. Acad. Sci. USA119(34)e2207841119(2022) |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
|