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| | Lycasin Basic information |
| Product Name: | Lycasin | | Synonyms: | Lycasin;LYCASIN,HYDROGENATEDPOLYSACCHARIDEFRACTION | | CAS: | 9053-46-7 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Lycasin Structure]() |
| | Lycasin Chemical Properties |
| solubility | Miscible with ethanol (provided the ethanol concentration
is less than 55%), glycerin, propylene glycol, and water.
Insoluble in mineral and vegetable oils. |
| | Lycasin Usage And Synthesis |
| Chemical Properties | Maltitol solution is a colorless and odorless, clear viscous liquid. It
is sweet-tasting (approximately 75% the sweetness of sucrose). | | Production Methods | Maltitol solution is prepared by the hydrogenation of a highmaltose
syrup that is obtained from starch by enzymatic hydrolysis.
The maltitol solution produced from this process consists of the
hydrogenated homologs of the oligosaccharides contained in the
original syrup. | | Pharmaceutical Applications | Maltitol solution is used in oral pharmaceutical formulations as a
bulk sweetening agent, either alone or in combination with other
excipients, such as sorbitol. Maltitol solution is also used as a
suspending agent in oral suspensions as an alternative to sucrose
syrup since it is viscous, noncariogenic, and has a low calorific
value. It is also noncrystallizing and therefore prevents ‘cap-locking’
in syrups and elixirs.
Maltitol solution is additionally used in the preparation of
pharmaceutical lozenges,and is also used in confectionery and
food products. | | Safety | Maltitol solution is used in oral pharmaceutical formulations,
confectionery, and food products, and is considered to be less
cariogenic than sucrose.It is generally regarded as a nontoxic,
nonallergenic, and nonirritant material. However, excessive oral
consumption (more than 50g daily) may cause flatulence and
diarrhea.
The WHO, in considering the safety of maltitol solution, did not
set a value for the acceptable daily intake since the levels used in
food to achieve a desired effect were not considered a hazard to
health.
LD50 (rat, IP): 20 g/kg | | storage | Maltitol solution is stable for at least 2 years at room temperature
and pH 3–9. Following storage for 3 months at 50°C, maltitol
solution at pH 2 underwent slight hydrolysis (1.2%) and became
yellow colored. At pH 3, and the same storage conditions, no color
change was apparent although very slight hydrolysis occurred
(0.2%). At pH 4–9, no hydrolysis occurred although a very slight
yellow color was formed under alkaline conditions.
Formulations containing maltitol solution should be preserved
with an antimicrobial preservative such as sodium benzoate or a
mixture of parabens. Maltitol solution is noncrystallizing.
Maltitol solution should be stored in a well-closed container, in a
cool, dry place. | | Regulatory Status | Accepted for use in confectionery, foods, and nonparenteral
pharmaceutical formulations in Europe and the USA. Included in
the Canadian List of Acceptable Non-medicinal Ingredients. |
| | Lycasin Preparation Products And Raw materials |
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