7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸
中文名称 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 |
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中文同义词 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸;帕替麦布;化合物 T28290 |
英文名称 | 2-[7-(2,2-dimethylpropanoylamino)-4,6-dimethyl-1-octyl-2,3-dihydroindo l-5-yl]acetic acid |
英文同义词 | 2-[7-(2,2-dimethylpropanoylamino)-4,6-dimethyl-1-octyl-2,3-dihydroindo l-5-yl]acetic acid;PactiMib;pactimibe;7-[(2,2-Dimethyl-1-oxopropyl)amino]-2,3-dihydro-4,6-dimethyl-1-octyl-1H-indole-5-acetic acid;Pactimibe free base;1H-Indole-5-acetic acid, 7-[(2,2-dimethyl-1-oxopropyl)amino]-2,3-dihydro-4,6-dimethyl-1-octyl- |
CAS号 | 189198-30-9 |
分子式 | C25H40N2O3 |
分子量 | 416.6 |
EINECS号 | |
相关类别 | |
Mol文件 | 189198-30-9.mol |
结构式 | ![]() |
7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 性质
沸点 | 604.4±55.0 °C(Predicted) |
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密度 | 1.071 |
储存条件 | 4°C, away from moisture |
溶解度 | 二甲基亚砜:200 mg/mL(480.08 mM) |
酸度系数(pKa) | 4.00±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
ACAT1 4.9 μM (IC 50 ) |
ACAT2 3.0 μM (IC 50 ) |
ACAT 2 μM (IC 50 , in the liver) |
ACAT 2.7 μM (IC 50 , in macrophages) |
ACAT 4.7 μM (IC 50 , in THP-1 cells) |
oleoyl-CoA 5.6 μM (Ki) |
cholesteryl ester formation 6.7 μM (IC 50 ) |
Pactimibe sulfate (CS-505) induces moderate ACAT inhibition in monocyte-derived macrophages, leading to the suppression of foam cell formation.
Pactimibe sulfate (CS-505; 60 and 200 mg/kg/day; oral gavage; twice a day; 12 weeks) induces an inhibition for ACAT-1 and ACAT-2, causing a reduction of plasma cholesterol but no influence on macrophage- or collagen-positive areas.
Animal Model: | Male C57BL/6J ApoE −/− mice aged 8-week-old |
Dosage: | 60 and 200 mg/kg/day |
Administration: | Oral gavage; twice a day; 12 weeks |
Result: | Decreased plasma cholesterol levels by 39% and 74% at the administration of 60 and 200 mg/kg/day. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-100401 | Pactimibe | 1 mg | 2045元 | |
2024/04/30 | HY-100401 | 7-[(2,2-二甲基-1-氧代丙基)氨基]-2,3-二氢-4,6-二甲基-1-辛基-1H-吲哚-5-乙酸 Pactimibe | 189198-30-9 | 5mg | 4500元 |