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OPC 21268

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OPC 21268 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:OPC 21268
CAS:131631-89-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:OPC 21268
CAS:131631-89-5
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:OPC-21268
CAS:131631-89-5
Purity:99% Package:5KG;1KG Remarks:OPC-21268
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:OPC-21268
CAS:131631-89-5
Purity:98% Package:5mg Remarks:V26933
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:Fuscoside
CAS:131631-89-5
Purity:NLT 98% Remarks:MC517539
OPC 21268 Basic information
Product Name:OPC 21268
Synonyms:1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one;1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate;OPC-21268 hydrate;N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide;OPC 21268;N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide;OPC 21268;OPC-21268;OPC21268
CAS:131631-89-5
MF:C26H31N3O4
MW:449.54
EINECS:
Product Categories:
Mol File:131631-89-5.mol
OPC 21268 Structure
OPC 21268 Chemical Properties
Boiling point 772.5±60.0 °C(Predicted)
density 1?+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka16.17±0.46(Predicted)
form powder
color white to off-white
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50
Safety Statements 61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
OPC 21268 Usage And Synthesis
DescriptionOPC 21268 is a nonpeptide antagonist of vasopressin V1 receptors (IC50 = 0.4 μM in rat liver membranes). It is selective for V1 over V2 receptors (IC50 = >100 μM in kidney membranes). It is also selective for rat over human V1 receptors (Kis = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID50 = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.
UsesOPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist.
storageStore at +4°C
OPC 21268 Preparation Products And Raw materials
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