| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:S-p-Bromobenzylglutathione cyclopentyl diester
CAS:166038-00-2
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:SML1306
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
CAS:166038-00-2
Purity:98% (HPLC) Package:25mg;5mg Remarks:NULL
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:BrBzGCp2
CAS:166038-00-2
Purity:98% Package:5mg;10mg;25mg;50mg;100mg
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| | S-4-bromobenzylglutathione cyclopentyl diester Basic information |
| Product Name: | S-4-bromobenzylglutathione cyclopentyl diester | | Synonyms: | S-4-bromobenzylglutathione cyclopentyl diester;BBGD;BBGC;BrBzGCp2;S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC);Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI);S-p-Bromobenzylglutathione cyclopentyl diester;BrBzGCp2,BrBzGCp-2 | | CAS: | 166038-00-2 | | MF: | C27H38BrN3O6S | | MW: | 612.58 | | EINECS: | | | Product Categories: | | | Mol File: | 166038-00-2.mol |  |
| | S-4-bromobenzylglutathione cyclopentyl diester Chemical Properties |
| Boiling point | 790.6±60.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 250 mg/mL (408.11 mM) | | form | powder | | pka | 12.84±0.46(Predicted) | | color | white to beige |
| | S-4-bromobenzylglutathione cyclopentyl diester Usage And Synthesis |
| Uses | S-p-Bromobenzylglutathione cyclopentyl diester has been used as an inhibitor of glyoxalase 1?(GLO-1) enzyme to treat HL-1 cardiomyocytes for stimulating aging-based glycative stress. It has also been used as an inhibitor of GLO-1 in hepatic stellate cells. | | Biochem/physiol Actions | S-p-Bromobenzylglutathione cyclopentyl diester (BBGC) is a cell-permeable inhibitor of Glyoxalase 1 (GLO1), an enzyme that detoxifies methylglyoxal, a toxic side-product of glycolysis that induces apoptosis at high levels and has been linked to arterial atherogenesis in diabetics. However, tumors use GLO as well and overexpression of GLO1 has been reported in a number of cancers, so GLO1 inhibitors including BBCG have been investigated as possible anticancer agents. Recent studies have indicated that methylglyoxal has some beneficial effects at low levels with GABAA receptor agonist activity, and that GLO1 inhibition with BBGC can reduce anxiety-like behavior and decrease antiseizure activity. S-p-bromobenzylglutathione cyclopentyl diester should be an inportant tool to study the glyoxalase system. |
| | S-4-bromobenzylglutathione cyclopentyl diester Preparation Products And Raw materials |
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