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CP 471,474

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CP 471,474 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CP-471474
CAS:210755-45-6
Package:1mg;78USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
CAS:210755-45-6
Purity:above 99% Package:1g;2USD
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:CP-471474
CAS:210755-45-6
Package:100Mg,10Mg
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:CP 471474;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]aMino]-N-hydroxy-2-MethylpropanaMide
CAS:210755-45-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:CP-471474
CAS:210755-45-6
Purity:98%

CP 471,474 manufacturers

  • CP-471474
  • CP-471474 pictures
  • $78.00 / 1mg
  • 2024-10-28
  • CAS:210755-45-6
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
CP 471,474 Basic information
Product Name:CP 471,474
Synonyms:PF-1626077;CP 471,474;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
CAS:210755-45-6
MF:C16H17FN2O5S
MW:368.38
EINECS:
Product Categories:Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals;Sulfur & Selenium Compounds;Heterocycles
Mol File:210755-45-6.mol
CP 471,474 Structure
CP 471,474 Chemical Properties
Melting point 135-137°C (dec.)
density 1.375±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥20mg/mL
pka9.33±0.50(Predicted)
form powder
color white to off-white
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 1
MSDS Information
CP 471,474 Usage And Synthesis
DescriptionCP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.
Chemical PropertiesWhite Solid
UsesA broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
Biochem/physiol ActionsCP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
CP 471,474 Preparation Products And Raw materials
Tag:CP 471,474(210755-45-6) Related Product Information
4-Fluoro-3-phenoxybenzaldehyde 4-PHENOXYBENZENESULFONYL CHLORIDE 2-Phenoxyethanol