| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Water Channel Aquaporin 2 antibody produced in rabbit
Purity:IgG fraction of antiserum, lyophilized powder Package:.2ML Remarks:A7310-.2ML
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:IgG fraction of antiserum, lyophilized powder
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
BD Biosciences
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| Tel: |
1 877 232 8995 U.S. orders |
| Email: |
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| Products Intro: |
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| Company Name: |
Nacalai Tesque, Inc.
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| Tel: |
81 75 251 1723 |
| Email: |
info-tech@nacalai.co.jp |
| Products Intro: |
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| | ANTI-AQUAPORIN 2 Basic information |
| | ANTI-AQUAPORIN 2 Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder |
| | ANTI-AQUAPORIN 2 Usage And Synthesis |
| Uses | Anti-Water Channel Aquaporin 2 antibody is also suitable for use in chemiluminescent western blot (1:200-1:1000), and immunoblot. | | General Description | Aquaporin 2 (AQP2) is a water channel protein that regulates water balance in renal connecting tubules and collecting ducts. AQP2 is activated by anti-diuretic hormone and subsequently facilitates water inflow in renal cells. This protein also interacts with integrin to modulate epithelial cell morphogenesis and cell movement . Anti-Water Channel Aquaporin 2 antibody recognizes aquaporin 2 from rat by immunoblotting. The antibody also reacts with mouse and human AQP2. | | Biochem/physiol Actions | Aquaporin (AQP2) N-terminal region plays a key role in trafficking. The C-terminal phosphorylation is crucial for the water permeability function of the apical membrane. Also, ubiquitination at lysine 270 is needed for AQP2 sorting and degradation in lysosomes or elimination through exosomes. Mutation in AQP2 gene is implicated in congenital nephrogenic diabetes insipidus (NDI), a water balance disorder. The functional dysregulation of AQP2 is also correlated to preeclampsia, congestive heart failure and liver cirrhosis. |
| | ANTI-AQUAPORIN 2 Preparation Products And Raw materials |
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