FX12

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Company Name:	Shanghai Yifei Biotechnology Co. , Ltd.
Tel:	021-65675885 18964387627
Email:	customer_service@efebio.com
Products Intro:	Product Name:FX12 CAS:1807639-36-6 Purity:98% Package:10mg;50mg

FX12 Basic information

Product Name:	FX12
Synonyms:
CAS:	1807639-36-6
MF:
MW:	0
EINECS:
Product Categories:
Mol File:	Mol File

FX12 Chemical Properties

Safety Information

MSDS Information

FX12 Usage And Synthesis

Uses

RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1].

References

[1] Ruan J, et al. A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase. Mol Biol Cell. 2022 Nov 1;33(13):ar120. DOI:10.1091/mbc.E22-06-0233

FX12 Preparation Products And Raw materials

Tag:FX12(1807639-36-6) Related Product Information

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FX12

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