| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Cofilin
Purity:IgG fraction of antiserum, buffered aqueous solution Package:0.2mL Remarks:C8736
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| Company Name: |
Absin Bioscience Inc.
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| Tel: |
021-38015121 15000105423 |
| Email: |
chenjw@absin.cn |
| Products Intro: |
Product Name:Cofilin antibody
Package:50ul Remarks: 见爱必信官网
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| Company Name: |
Shanghai Bohu Biotechnology Co., LTD
|
| Tel: |
021-57763112 13585886131 |
| Email: |
3004987436@qq.com |
| Products Intro: |
Product Name:Anti-Cofilin
Purity:1mg/1m Package:100ug/;200ug/
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| | ANTI-COFILIN Basic information |
| | ANTI-COFILIN Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-COFILIN Usage And Synthesis |
| Uses | Anti-Cofilin antibody has been used in western blotting. | | Uses | Anti-Cofilin antibody has been used:
- for immunostaining of chick neurons. It is used as a primary antibody
- for western blotting of protein isolated from mouse hippocampi cells, rat brain samples, human acute lymphoblastic T-cell line, human brain samples, head and neck squamous cell carcinoma cell line, HEK293T cells and renal epithelial cell lines
- for immunofluorescence studies in tissue samples from human brain
| | General Description | Cofilin is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. In mammals it has two isoforms: non-muscle (NM-CF, CF-L1) and muscle (M-CF, CF-L2). The protein is ubiquitiously present in tissues of eukaryotes and is especially abundant in neuronal tissues. It can shuttle between the cytoplasm and the nucleus in response to various stresses or signals, and may translocate from the cytoplasm to the plasma membrane in various cells. | | Biochem/physiol Actions | Cofilin binds stoichiometrically to monomeric G-actin and actin protomers. Cofilin intercalates between longitudinally associated actin monomers within the filament. Under specific conditions, It cleaves the filaments and accelerates actin subunits dissociation from their ‘pointed′ ends. It is essential for viability and vital for many cellular processes involving actin remodeling, such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis etc. Cofilin activity is regulated through reversible phosphorylation and dephosphorylation. In phosphorylated form, it is inactive and unable to bond with actin. Phosphorylation of cofilin is regulated by at least four protein kinases: LIM Kinase-1, LIM Kinase-2, Testicular Kinase-1, and Testicular Kinase-2. S-nitrosylation of cofilin is involved in vascular endothelial growth factor (VEGF)-stimulated endothelial cytoskeleton remodeling and migration. Over-expression of cofilin suppresses growth and invasion of non-small cell lung cancer. Dysregulation of cofilin is associated with neurodegeneration. |
| | ANTI-COFILIN Preparation Products And Raw materials |
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