盐酸头孢卡品酯
| 中文名称 | 盐酸头孢卡品酯 |
|---|---|
| 中文同义词 | 盐酸头孢卡培萘酯;头孢卡品酯盐酸盐 |
| 英文名称 | Cefcapene Pivoxil Hydrochloride |
| 英文同义词 | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-(((2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R,7R)-;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R-(6alpha,7beta(Z)))-;(6R,7R)-(Pivaloyloxy)methyl 7-((Z)-2-(2-aminothiazol-4-yl)pent-2-enamido)-3-((carbamoyloxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride;Cefcapinaxil hydrochloride |
| CAS号 | 147816-23-7 |
| 分子式 | C23H30ClN5O8S2 |
| 分子量 | 604.096 |
| EINECS号 | |
| 相关类别 | Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 147816-23-7.mol |
| 结构式 |  |
盐酸头孢卡品酯 性质
| 熔点 | 158-164°C |
|---|---|
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMSO（少量）、甲醇（少量）、水（少量） |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
Cefcapene pivoxil hydrochloride，一种抗生素，具有口服活性的第三代头孢菌素，具有广谱的抗菌 (anti-bacterial) 活性。Cefcapene pivoxil hydrochloride 可用于脓疱病 (PPP) 的研究。
IC50: bacterial
Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration.
| Animal Model: | Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×10 9 CFU) |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; 100mg/kg; 4 days |
| Result: | Was against H. influenzae colonization in mouse lung. |