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| | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol Basic information |
| Product Name: | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol | | Synonyms: | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol;Micranthine;2H-22,26-Epoxy-1,24:12,15-dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinolin-9-ol, 3,4,4a,5,16a,17,18,19-octahydro-21-methoxy-17-methyl-, (4aR,16aR)- (9CI) | | CAS: | 36104-64-0 | | MF: | C34H32N2O5 | | MW: | 548.64 | | EINECS: | | | Product Categories: | | | Mol File: | 36104-64-0.mol |  |
| | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol Chemical Properties |
| Melting point | 194-196° | | alpha | D22 -231° (c = 0.7 in chloroform) | | density | 1.284±0.06 g/cm3(Predicted) | | pka | 9.42±0.20(Predicted) |
| | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol Usage And Synthesis |
| Description | A constituent of Daphnandra rnicrantha Benth, this alkaloid crystallizes as
colQurless needles from Me2CO or AcOEt and has the above melting point after
sintering at 185°C. When crystallized from CHC13 the base contains 0.5 mole of
solvent which may be removed by dryJng at 100°C. The alkaloid is laevorotatory
with [0!]~2 - 231° (CHCI3). It is readily soluble in CHC13 or EtOH, sparingly so
in MeOH, C6H6 or AcOEt and almost insoluble in Et20. The only crystalline
salts so far obtained are the normal sulphate decahydrate, fine colourless needles
from H20, m.p. 312°C (dec.) and the acid sulphate, colourless needles with 2.5
H20, m.p. 305-31 O°C (dec.). With Frohde's reagent, the base gives an indigo
colour gradually changing to green. The original formula of C34Hn06N2 has
recently been revised to that given. | | References | Pyman., J. Chern. Soc., 105,1679 (1914)
Bick, Todd., ibid, 1606 (1950)
Revised structure:
Bick et aI., Tetrahedron Lett., 33 (1972)
Bick et al., J. Chern. Soc., Perkin I, 2884 (1972) |
| | (1α)-6',7-Oxy-6-methoxy-2-methyloxyacanthan-12'-ol Preparation Products And Raw materials |
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