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| | ANTI-HUMAN CD42B Basic information |
| Product Name: | ANTI-HUMAN CD42B | | Synonyms: | ANTI-HUMAN CD42B, PLATELET GLYCOPROTEIN IB;ANTI-HUMAN CD42B;ANTI-HUMAN PLATELET GLYCOPROTEIN 1B;ANTI-HUMAN PLATELET GLYCOPROTEIN IB;ANTI-CD42B;ANTI-CD42B, HUMAN;ANTI-CD42B, HUMAN (WS IV);ANTI-CD42B MOUSE MAB | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HUMAN CD42B Structure]() |
| | ANTI-HUMAN CD42B Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | ANTI-HUMAN CD42B Usage And Synthesis |
| Uses | The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. | | General Description | The mouse monoclonal antibody AK2 recognizes CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d. | | Biochem/physiol Actions | Cluster of differentiation 42b (CD42b) clustering promotes integrin αIIbβ3-dependent platelet aggregation, phagocytosis and rapid platelet clearance in the liver. The encoded protein acts as a platelet receptor for von Willebrand factor (VWF) and other ligands present in circulation. Mutation in the gene leads to autosomal recessive Bernard-Soulier syndrome. CD42b interacts with plasma hemoglobin (Hb) and enhances platelet activation and apoptosis in a concentration-dependent manner and also regulates platelet functions. |
| | ANTI-HUMAN CD42B Preparation Products And Raw materials |
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