| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:IgG fraction of antiserum, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-PRESENILIN 1 (PS1, S182) Basic information |
| | ANTI-PRESENILIN 1 (PS1, S182) Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-PRESENILIN 1 (PS1, S182) Usage And Synthesis |
| Uses | Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:
- immunostaining
- immunofluorescence detection
- immunohistochemistry
- immunoblotting
| | General Description | Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14. | | Biochem/physiol Actions | The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2. |
| | ANTI-PRESENILIN 1 (PS1, S182) Preparation Products And Raw materials |
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